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Evidence Report/Technology Assessment: Number 42
Defining and Managing Chronic Fatigue Syndrome

Summary:  Under its Evidence-based Practice Program, the Agency for Healthcare Research and Quality (AHRQ) is developing scientific information for other agencies and organizations on which to base clinical guidelines, performance measures, and other quality improvement tools. Contractor institutions review all relevant scientific literature on assigned clinical care topics and produce evidence reports and technology assessments, conduct research on methodologies and the effectiveness of their implementation, and participate in technical assistance activities.

Overview: This evidence report is a systematic review that summarizes scientific literature about the following aspects of chronic fatigue syndrome (CFS) in adults:

    • Case definitions.
    • Prevalence and natural history.
    • Treatment.

In an effort to organize and clarify this body of research knowledge, the Agency for Healthcare Research and Quality (AHRQ) contracted for this evidence-based review with the San Antonio Evidence-based Practice Center (EPC). The National Institute of Allergy and Infectious Diseases nominated the topic for an evidence-based review.

Read the initial brief report.  The full evidence report is expected to be available in Winter 2002. At that time, printed copies may be obtained free of charge from the AHRQ Publications Clearinghouse by calling 800-358-9295.  Requesters should ask for Evidence Report/Technology Assessment No. 42, Defining and Managing Chronic Fatigue Syndrome (AHRQ Publication No. 01- E061). Internet users will be able to access the report online through AHRQ's site.

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